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  • Title: Hormone-induced modifications of free tyrosine in the rat thyroid gland.
    Author: Hodge JV, Melmon KL, Sjoerdsma A.
    Journal: J Physiol; 1969 Jul; 203(1):1-12. PubMed ID: 5821874.
    Abstract:
    The concentrations of free tyrosine in liver, muscle, kidney and thyroid gland were determined in separate groups of rats maintained on a low iodine diet and treated with intraperitoneal injections of thyroxine (T 4), thyrotrophin (TSH) and TSH plus propylthiouracil (PTU). Groups of hypophysectomized rats also were given T 4. Significant changes in tissue tyrosine were generally confined to the thyroid gland. Animals treated with T 4 showed a decrease of mean thyroid tyrosine from 113.3 +/- 17.9 (S.D.) mug/g wet weight of gland to 76.2 +/- 5.7 mug/g (P < 0.01). Although there was little change in content when TSH was given alone, a significant increase in tyrosine levels was observed when TSH plus PTU were administered (P < 0.01). In hypophysectomized rats thyroid tyrosine decreased and was further lowered (to 46.0 +/- 3.1 mug/g; P < 0.05) by T 4 treatment. When tyrosine concentrations were expressed in relation to ribonucleic acid (RNA) or protein content of the assayed gland, all differences in tyrosine content became greater.
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