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  • Title: Creatinine clearance in renal disease. A reappraisal.
    Author: Kim KE, Onesti G, Ramirez O, Brest AN, Swartz C.
    Journal: Br Med J; 1969 Oct 04; 4(5674):11-4. PubMed ID: 5822077.
    Abstract:
    To determine the validity of endogenous creatinine clearance as a measure of glomerular filtration rate in patients with renal disease 308 simultaneous determinations of inulin clearance and endogenous creatinine clearance were reviewed and analysed. The ratio of creatinine clearance/inulin clearance increased progressively with the decline in inulin clearance, while the finding of a normal endogenous creatinine clearance masked a definite but mild decrease of glomerular filtration rate in 42% of the patients and a moderate decrease of glomerular filtration rate in 23%. This indicates that with declining glomerular filtration rates the endogenous creatinine clearance progressively overestimates actual glomerular filtration rates. Hence a single determination of creatinine clearance can be misleading as a screening measurement of glomerular filtration rate.
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