These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice.
    Author: Ueda H, Amano H, Shiomi H, Takagi H.
    Journal: Eur J Pharmacol; 1979 Jun 15; 56(3):265-8. PubMed ID: 582583.
    Abstract:
    To determine accurately the central analgesic effects of opioid peptides, we devised a special technique for intracisternal administration of drugs to conscious mice. When this method was utilized we found that a series of endogenous opioid peptides and enkephalin analogues, (D-Ala2,Met5)-enkephalinamide and (D-Met2,Pro5)-enkephalinamide produced dose-related analgesic effects, as determined by the tail pinch test. These effects were antagonized by pretreatment with naloxone 0.5 mg/kg s.c. This technique should be a most accurate one for the determination of central analgesic effects of various drugs in conscious mice.
    [Abstract] [Full Text] [Related] [New Search]