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  • Title: [Effects of benzarone on the chloroform edema of the mouse and on the petechiae test in the guinea pig (author's transl)].
    Author: Felix W, Hällfritzsch K.
    Journal: Arzneimittelforschung; 1978; 28(12):2297-9. PubMed ID: 582946.
    Abstract:
    1. Chloroform edema. On the backskin of a mouse a wheal was produced by locally applied chloroform containing a fluid rich in protein. It was investigated whether a series of edema-protective drugs, i.e., drugs with anti-inflammatory effect, corticoids, and vascular-active drugs, could inhibit the development of the wheal edema. Only benzarone proved a statistically significant inhibition. The fact that other drugs proved less effective or not at all, could be based on the difference between the mechansim of the chloroform edema and that of other edema models. A reciprocal effect between benzarone and chloroform may be considered as well. 2. Petechiae test. A vitamin C-free nutrition over 3 weeks did not increase the "brittleness of capillaries" in the backskin of guinea pigs; whereas 50 mg benzarone/kg fed daily over a period of 3 weeks caused a significant decrease in the number of petechiae compared to that in the controls. This effect, most likely, was not due to an improved stability of the capillaries but was based on the reduced blood circulation of the skin.
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