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  • Title: [Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)].
    Author: Wendt H, Kessler J.
    Journal: Arzneimittelforschung; 1979; 29(5):846-8. PubMed ID: 582987.
    Abstract:
    A comparative study (occlusion test according to Marples and Kligman) was conducted in 100 test subjects with several formulations of isoconazole nitrate. The following results were obtained: 1. There are no differences in efficacy between the free base, isoconazole, and the nitrate. 2. Increasing the active substance concentration of isoconazole nitrate above 1% produced a noticeable increase in its effect so that 2% and 4% preparations are appropriate for particular uses. 3. 1% isoconazole nitrate (Travogen cream, Gyno-Travogen cream) is more effective than a commercial cream containing 1% clotrimazole. 4. The addition of a corticosteroid (diflucortolone-21-valerate 0.1%, Travocort cream) does not influence the action of isoconazole nitrate.
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