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  • Title: Thyroid antigen associated immune complex glomerulonephritis in Graves' disease.
    Author: Horvath F, Teague P, Gaffney EF, Mars DR, Fuller TJ.
    Journal: Am J Med; 1979 Nov; 67(5):901-4. PubMed ID: 583094.
    Abstract:
    A 60 year old hyperthyroid black woman with long-standing Graves' disease treated with methimazole presented with anasarca and congestive heart failure. She was found to have the nephrotic syndrome with a urinary protein excretion of 32 g/day. Light and electron microscopy revealed a stage II membranous glomerulopathy. Direct and indirect immunofluorescence demonstrated immunoglobulin G (IgG), immunoglobulin M (IgM), third component of complement and thyroglobulin in a granular diffuse pattern consistent with an immune complex glomerulonephritis. Total thyroidectomy led to a decrease in proteinuria with little change in glomerular filtration rate during an 11 month follow-up period. We believe this to be the first report of immune complex glomerulonephritis associated with thyroid antigen in Graves' disease.
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