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  • Title: Relationship between the antitrichinellous effect of seven derivates of benzimidazolecarbamates and their chemical structure.
    Author: Spaldonová R, Corba J.
    Journal: Folia Parasitol (Praha); 1979; 26(2):145-9. PubMed ID: 583335.
    Abstract:
    The efficacy of seven more recently developed anthelmintics of the benzimidazolecarbamate group, i. e., parbendazole, mebendazole, fenbendazole, oxibendazole, cambendazole, oxfendazole and albendazole, has been tested in a series of experiments on white mice artifically infected with Trichinella spiralis. Our results disclosed a relationship between their anthelmintic effect and their chemical structure. This finding might be of importance in a targeted synthesis of new, effective, derivates of benzimidazole, e. g., in the therapy of trichinellosis and in the choice of the most effective drug.
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