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  • Title: Comparative pharmacokinetics and relative bioavailability for different preparations of nitrofurantoin.
    Author: Maier-Lenz H, Ringwelski L, Windorfer A.
    Journal: Arzneimittelforschung; 1979; 29(12):1898-901. PubMed ID: 583541.
    Abstract:
    In a single-dose study three different dosage forms of nitrofurantoin tablets are compared in order to attain a longer duration of efficacy by means of sustained-release dosage forms. In particular, bioavailability and the rate constants are estimated and show for one dosage form significant advantages. The measured serum and urine concentration levels are evaluated with a two-compartment model of first order which assumed the sustained release of the drug in an exponential manner.
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