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  • Title: Letter: Alpha fetoprotein in amniotic fluid and maternal serum.
    Author: Buffe D, Rimbaut C, Henrion R, Boue J, Boue A.
    Journal: N Engl J Med; 1976 Jul 01; 295(1):51. PubMed ID: 58380.
    Abstract:
    Additional findings concerning the evolution alpha fetoprotein (AFP) are reported in this letter. AFP levels of 440 amniotic fluids and 469 maternal sera were studied at different gestational ages. In addition, amniotic fluids and serum samples of 180 pregnant women were collected on the same day. Comparative study of amniotic fluid and maternal sera levels of AFP led to establishment of parallelism between these values from Week 17-20 of gestation. During this period, the ratio of amniotic fluid:maternal serum AFP was always between 100 and 250, whereas, it was less than 80 after Week 21 and greater than 400 before the 16th week. Fetal blood contamination of 2 samples resulted in high-for-date AFP levels, and subsequent amniocenteses were normal for AFP. In 2 twin pregnancies, the AFP value was normal in amniotic fluid and increased in maternal serum. The ratio was low for dates--about 1/2 normal. In cases with abnormalities the ratio was abnormal. High AFP levels in serum with normal amniotic values in 2 pregnant patients with renal disease were found: in these cases, the ratio was low for gestational age, but not as low as that observed in cases of intrauterine death. Ratios were too high for gestational age in cases of anencephaly and umbilical hernia.
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