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  • Title: Myelin Membrane: a molecular abnormality.
    Author: O'Brien JS, Sampson EL.
    Journal: Science; 1965 Dec 17; 150(3703):1613-4. PubMed ID: 5866661.
    Abstract:
    Myelin was isolated from cerebral white matter from a patient who had died of metachromatic leukodystrophy, and its lipid composition was analyzed. Although the lipid content was nearly normal, the myelin contained a three- to fourfold excess of cerebroside sulfate and a threefold deficiency of cerebroside compared to normal myelin. The deficiency of cerebroside and the excess of cerebroside sulfate may account for defective myelination in this disease.
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