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  • Title: [Effect of Kupffer cell blockade at different periods following partial hepatectomy on regeneration of hepatocytes].
    Author: Maianskiĭ DN, Shcherbakov VI, Mirokhanov IuM.
    Journal: Biull Eksp Biol Med; 1977 Nov; 84(11):616-8. PubMed ID: 588743.
    Abstract:
    In male Wistar rats, weighing 140-160 g, the block of the liver mononuclear phagocyte system (MPS) was carried out by means of "carbonyl iron" (type R-100F, particle size 1-1.5 micron). It was induced 2 hours before or 3 and 18 hours after partial hepatectomy. Iron injection previously or at the early prereplicative regeneration period led to a significant delay of the hepatocyte nucleus labeling and mitotic indices peaks against the background of an overall depression of hepatocyte proliferation. The MPS block during the intensive DNA synthesis by regenerating liver hepatocytes was less effective. The facts testify to the importance of Kupffer's cells in the regulation of the reparative liver regeneration.
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