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  • Title: A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis.
    Author: Harman AE, Priestly BG, Frewin DB.
    Journal: Clin Exp Pharmacol Physiol; 1977; 4(6):593-6. PubMed ID: 589875.
    Abstract:
    1. Half-life, apparent volume of distribution and metabolic clearance rate for antipyrine elimination were reliably estimated from either plasma or saliva samples. 2. Pharmacokinetic analysis of antipyrine from saliva utilizing a simple and sensitive colourimetric technique provided a convenient method for assessing the activity of hepatic microsomal drug-metabolizing enzymes.
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