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  • Title: Efficacy, side-effects, plasma and blood levels of maprotiline (Ludiomil).
    Author: Miller PI, Beaumont G, Seldrup J, John V, Luscombe DK, Jones R.
    Journal: J Int Med Res; 1977; 5 Suppl 4():101-11. PubMed ID: 590605.
    Abstract:
    Two trials of maprotiline (Ludiomil) were performed in general practice. In the first study depressed patients were given either 75 mg of maprotiline in a single dose or 25 mg three times daily. Assessments of the severity of depression and of side-effects were made initially and following 1, 2 and 4 weeks' treatment. At each assessment measurements of plasma levels of maprotiline were made. A second trial was performed in which some patients receiving 75 mg single dose of maprotiline had whole blood levels of maprotiline assayed. Steady-state levels of maprotiline were achieved after one week but these levels showed considerable individual variability. No clear correlation emerged between clinical response, side-effects and plasma or blood levels. Some of the factors which may be responsible are discussed.
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