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  • Title: Radioactive components in the acid-soluble fraction of mouse liver cytosol after dimethylnitrosamine[methyl-14C] administration.
    Author: Daugherty JP, Clapp NK, Zehfus MH, Brock SE.
    Journal: Gan; 1977 Oct; 68(5):697-701. PubMed ID: 590686.
    Abstract:
    The acid-soluble components of mouse-liver cytosol, prepared at time intervals after intragastric administration of a single carcinogenic dose of 14C-dimethylnitrosamine, were separated by column chromatography. The columns were calibrated with known in vitro metabolites of the nitrosamine, and the elution profiles were compared with those of the mouse-liver system. The results suggest that the 14C-methyl label is transferred to many of the same compounds as identified in vitro, but that numerous other labeled compounds are also present. The possible significance of these metabolites to the pathogenic processes induced by dimethylnitrosamine has yet to be determined.
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