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  • Title: Tetrodotoxin and manganese ions: effects on electrical activity and tension in taenia coli of guinea pig.
    Author: Nonomura Y, Hotta Y, Ohashi H.
    Journal: Science; 1966 Apr 01; 152(3718):97-8. PubMed ID: 5910020.
    Abstract:
    Tetrodotoxin, at concentrations up to 5 x 10(-6) gram per milliliter, has no effect on the spontaneous discharge in the smooth muscle of taenia coli. However, the spontaneous discharge is abolished by Mn(++) at a concentration of 0.5 millimole per liter. The contraction induced by immersing the muscle in isotonic KCl solution is also suppressed in the presence of Mn(++). Because Mn(++) is a specific suppressor of the spike induced by Ca(++) and tetrodotoxin is an inhibitor of the spike induced by Na(+), we suggest that Ca(++) is a charge carrier in the production of spike potential in the smooth muscle and that the entry of intervening Ca(++) through the membrane acts as a trigger for the contraction of smooth muscle.
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