These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of amino acids on sugar absorption.
    Author: Hindmarsh JT, Kilby D, Wiseman G.
    Journal: J Physiol; 1966 Sep; 186(1):166-74. PubMed ID: 5914250.
    Abstract:
    1. Sacs of everted mid-small intestine of the hamster have been used to study the effect of amino acids on sugar absorption.2. The sugars employed were D-glucose, D-galactose, 3-O-methyl-D-glucose, D-fucose, L-glucose, alpha-glucoheptose, L-fucose, D-mannose and L-sorbose. The amino acids were L- and D-histidine, L- and D-methionine, L- and D-alanine, L- and D-valine, L- and D-glutamic acid, L-leucine, L-proline, L-ornithine and L-aspartic acid.3. Actively absorbed amino acids considerably inhibit the transport of actively absorbed sugars. The results give support for the view that D-histidine and L-glucose are actively transferred. Passively absorbed amino acids and sugars are not involved.4. As L-glutamic and L-aspartic acids in the mucosal fluid have no inhibitory effect on D-glucose absorption, although mucosal fluid L-alanine is quite potent, the step at which the latter exerts its inhibitory action must be before that at which the intracellular transamination of L-glutamic and L-aspartic acids occurs. It would seem likely, therefore, that L-alanine interferes with the process by which epithelial cells capture and concentrate sugars at the luminal border.5. More than one active transfer system may exist for D-glucose.6. The influence of actively absorbed L-amino acids on D-glucose active transport seems to be in some way related to the efficiency with which the amino acids are themselves concentrated.7. Inhibition of D-glucose active absorption by an amino acid may be a simple test of an amino acid's participation in an active transport system.
    [Abstract] [Full Text] [Related] [New Search]