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  • Title: Tallysomycin, a new antitumor antibiotic complex related to bleomycin. I. Production, isolation and properties.
    Author: Kawaguchi H, Tsukiura H, Tomita K, Konishi M, Saito K.
    Journal: J Antibiot (Tokyo); 1977 Oct; 30(10):779-88. PubMed ID: 591443.
    Abstract:
    The unusual actinomycetes strain No. E465-94 produced a complex of new glycopeptide antibiotics tallysomycin, which was separated by CM-Sephadex chromatography into two major components, A (C68H107N21O27S2) and B (C62H95N19O26S2). They were isolated first in a copper-chelated form and showed physico-chemical properties similar to those of the bleomycin-group of antibiotics. Tallysomycin exhibited broad antibacterial and antifungal activity, and was highly active in vivo against bacterial infections in mice. Tallysomycins A and B demonstrated potent activity in the prophage induction of lysogenic bacteria.
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