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  • Title: Synthesis and antibacterial activities of 1-N [(S)-omega-amino-2-hydroxyalkyl] kanamycin A derivatives.
    Author: Richardson K, Jevons S, Moore JW, Ross BC, Wright JR.
    Journal: J Antibiot (Tokyo); 1977 Oct; 30(10):843-6. PubMed ID: 591447.
    Abstract:
    Four 1-N-aminohydroxy-alkyl derivatives of kanamycin A were prepared and their in vitro activities against aminoglycoside-sensitive and aminoglycoside-resistant organisms were compared with amikacin. 1-N-[(S)-4-Amino-2-hydroxybutyl] kanamycin A (Fig. 1, compound 2, code no. UK-18,892) was equipotent to amikacin in all these tests and in mouse protection studies.
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