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  • Title: Topical therapy of ulcerative herpetic keratitis with human interferon.
    Author: Jones BR, Coster DJ, Falcon MG, Cantell K.
    Journal: Lancet; 1976 Jul 17; 2(7977):128. PubMed ID: 59189.
    Abstract:
    55 patients with dendritic ulcer have been treated in a double-blind randomised manner by minimal wiping debridement of their ulcers followed by daily application of either partially purified human interferon (P.I.N.F.) or placebo. There were 6 recurrences of epithelial herpetic disease in 30 patients who received P.I.N.F. and 13 in 25 who received placebo. This provides the long-awaited data proving the antiviral effect of exogenous interferon in treatment of naturally occurring viral disease in man, and furnishes a sighting shot on the lower edge of the target of effective therapy.
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