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  • Title: Adenovirus multiplication: inhibition by methisazone.
    Author: Bauer DJ, Apostolov K.
    Journal: Science; 1966 Nov 11; 154(3750):796-7. PubMed ID: 5919452.
    Abstract:
    Methisazone (5 to 40 microM) inhibited the multiplication of types 3, 7, 9, 11, 14, 16, 17, 21, and 28 adenovirus; SV15 (a simian adenovirus) was also inhibited. A study of adenovirus 11 under single-cycle conditions showed that multiplication of the virus, was completely inhibited by 30 microM methisazone when addition of the compound was delayed until 13 hours after infection. A survey showed that the structure-activity relations of the action of methisazone against adenoviruses and pox viruses are similar.
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