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  • Title: Hypolipidemic activity of 5-aryl-3-methylvaleric acid derivatives.
    Author: Dygos JH, Jett CM, Chinn LJ, Miller JE.
    Journal: J Med Chem; 1977 Dec; 20(12):1705-8. PubMed ID: 592342.
    Abstract:
    Several 5-aryl-3-methylvaleric acid derivatives have been shown to be more potent hypolipidemic agents than the previously reported 5-(4-biphenylyl)-3-methylvaleric acid (1). The most active compound in this series was 5-(4-phenylsulfonylphenyl)-3-methylvaleric acid (10) which lowered serum cholesterol levels 45% and serum triglyceride levels 60% in normal rats. Significant lowering of the serum triglyceride levels was the predominant effect noted with most of the compounds tested.
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