These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A study of the increased sensitivity of denervated and re-innervated muscle to depolarizing drugs.
    Author: Maclagan J, Vrbová G.
    Journal: J Physiol; 1966 Jan; 182(1):131-43. PubMed ID: 5937407.
    Abstract:
    1. The response of re-innervated muscles to depolarizing blocking drugs was studied.2. During the early stages of re-innervation the ;new' neuromuscular junctions are more sensitive to decamethonium and suxamethonium. The recovery from the block and the repolarization of the end-plate are markedly slowed.3. This increased sensitivity does not appear to be characteristic of all newly formed neuromuscular junctions. It was found that in new-born kittens the muscles are very insensitive to neuromuscular blocking drugs.4. It is concluded that the increased sensitivity of re-innervated muscles to depolarizing blocking drugs and the slow repolarization are due to a persistence of changes which developed during denervation.
    [Abstract] [Full Text] [Related] [New Search]