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  • Title: Mechanism of relaxant action of prostaglandin F2alpha on the guinea-pig isolated trachea.
    Author: Lo PY, Karim SM.
    Journal: Prostaglandins; 1977 Oct; 14(4):715-20. PubMed ID: 594374.
    Abstract:
    Prostaglandin F2alpha consistently produced a dose-related triphasic response in guinea-pig isolated tracheal chain preparations. The response consisted of an initial transient contraction followed by a transient relaxation, followed by a further contraction. The relaxant action was not due to adrenergic or histaminergic transmission, but might be due to a PG-like material released by the PGF 2alpha-induced contraction.
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