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  • Title: [Oxidative phase of pentose-phosphate cycle in sea mussel (mytilus edulis l.) (author's transl)].
    Author: Carrión-Angosto A, Silva Pando M, Rodríquez-Segade S, Ruiz-Amil M.
    Journal: Rev Esp Fisiol; 1977 Dec; 33(4):265-71. PubMed ID: 594483.
    Abstract:
    Glucose-6-phosphate dehydrogenase (E.C. 1.1.1.49) and 6-phosphogluconate dehydrogenase (E.C. 1.1.1.44) activities measured in tissue extracts from sea mussel exhibit a potential unbalance which could cause an accumulation of 6-phosphogluconate. Nevertheless elevated levels of this metabolite are not detected in mussel tissues. The Entner-Doudoroff pathway has not been found in hepatopancreas, adductor muscle and gill tissues. Hepatopancreas glucose-6-phosphate-dehydrogenase and 6-phosphogluconate dehydrogenase apparent kinetic parameters at 25 degrees C, were determined. The enzymes are competitively inhibited by NADPH with respect to NADP+. Oxidized Glutathione at nearly physiological concentrations counteracts NADPH inhibition.
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