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  • Title: [Study of histamine in asthma].
    Author: Parrot JL, Mordelet M, Santais MC, Ruff F.
    Journal: Allergol Immunopathol (Madr); 1976; 4(2):153-6. PubMed ID: 59539.
    Abstract:
    Histamine is generally considered as the principal chemical mediator in experimental allergy of type I and anaphylaxis. However, its part in human bronchial asthma remains discussed, because neither the dosage of histamine in blood, nor the use of antihistaminics have furnished any real evidence. This study is dealing with two elements: the importance of local bronchopulmonary phenomena, and the associated mediators also liberated in asthma, such as SRSA. ECFA, kinines, prostaglandins and disorders of balance between, on one hand, alpha and beta-actions of the catecholamines, and on the other hand, between the two main types of cyclic nucleotides. These considerations should allow a better approach of the asthma etiopathology and perhaps an improvement of its treatment.
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