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  • Title: Exceptionally high serum erythropoietin activity in an anephric patient with severe anemia.
    Author: Ortega JA, Malekzadeh MH, Dukes PP, Ma A, Pennisi AV, Fine RN, Shore NA.
    Journal: Am J Hematol; 1977; 2(3):299-306. PubMed ID: 596371.
    Abstract:
    An exceptionally high serum erythropoietin (EPO) activity was documented in an anephric patient with severe anemia who required transfusions every 4 weeks. The patient's serum EPO was comparable to normal human urinary EPO in the polycythemic mouse assay and was neutralized by an antiserum against EPO. The patient's serum inhibited EPO stimulated-heme synthesis by normal human marrow cells in vitro. This finding suggests that an inhibitor played an important role in causing the anemia of this uremic patient.
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