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  • Title: Studies of the "e" antigen in acute and chronic hepatitis.
    Author: Smith JL, Murphy BL, Auslander MO, Maynard JE, Schalm SS, Summerskill WH, Gitnick GL.
    Journal: Gastroenterology; 1976 Aug; 71(2):208-9. PubMed ID: 59674.
    Abstract:
    Sera from well individuals, including controls and asymptomatic HBsAg carriers, post-transfusion hepatitis cases, and chronic active liver disease patients were examined for the presence of "e" antigen and e antibody by rheophoresis. Our data confirm the specific association between the e determinant and hepatitis B infections and indicate that e antigen is closely associated with evidence of chronic hepatic dysfunction, in contrast to the association of e antibody with hepatic normalcy in HBsAg carriers. However, these correlations are not absolute and, therefore, it should not be inferred that all e antigen-positive individuals will develop chronic hepatitis nor, conversely, that presence of e antibody invariably protects against the development of chronic hepatitis.
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