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  • Title: Circannual variation in human erythrocyte adenosine aminohydrolase.
    Author: Nechaev A, Halberg F, Mittelman A, Tritsch GL.
    Journal: Chronobiologia; 1977; 4(3):191-8. PubMed ID: 598270.
    Abstract:
    In serially independent samples of blood from apparently healthy subjects controlled as to clock-hour of blood withdrawal but not as to any circannual changes in circadian state, human erythrocyte adenosine aminohydrolase undergoes a statistically significant circannual rhythm, which may or may not be aliased. This rhythm is also demonstrated in patients with a variety of neoplastic diseases and it occurs around a statistically significantly lower mesor in patients with a variety of malignant tumors investigated.
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