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  • Title: The effect of cyclophosphamide on the centromere separation sequence in Chinese hamster spermatogonia.
    Author: Singh JR, Miltenburger HG.
    Journal: Hum Genet; 1977 Dec 23; 39(3):359-62. PubMed ID: 598845.
    Abstract:
    The sequence of centromere separation in spermatogonial chromosomes of untreated and cyclophosphamide-treated Chinese hamsters is described. Centromeres of chromosome 1 and 2 separated much earlier than all other chromosomes, especially 6-8. Cyclophosphamide significantly inhibits the centromere separation in all chromosome groups but does not alter the sequence of separation.
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