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  • Title: [Changes in the antidiuretic activity of the blood in hypertensive crises and experimental arterial hypertension of hypothalamic origin].
    Author: Pershakova LP, Suchkov VV, Koplik EV.
    Journal: Kardiologiia; 1977 Oct; 17(10):27-31. PubMed ID: 599793.
    Abstract:
    The blood antidiuretic activity was studied in patients with hypertensive disease in a period between crises and during a hypertensive crisis. The antidiuretic activity of blood was found to be higher in patients who had crises than in those with no history of crises. Blood antidiuretic activity diminishes during a hypertensive crisis, which is evidently due to the inhibiting effect on the hypothalamus of the receptors of the cardiovascular system. Similar results were obtained in experiments in elevation of arterial pressure induced by electric stimulation of the hypothalamic nuclei. It is concluded that the antidiuretic hormone plays a pathogenetic role in hypertensive disease which is marked by the development of crises.
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