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  • Title: [Mechanism of the prophylactic effect of adaptation to altitude hypoxia on the development of hypertension].
    Author: Meerson FZ, Barbarash NA, Shorpin IuP.
    Journal: Kardiologiia; 1977 Dec; 17(12):71-9. PubMed ID: 599830.
    Abstract:
    It was shown in experiments on 200 albino rats that prolonged adaptation to the periodical effect of hypoxia in an altitude chamber always resulted in partial atrophy of the adrenal glomerular zone and decrease in the synthesis of mineralocorticoids in the adrenals and in their concentration in blood. At the same time, the size of the supraoptic hypothalamic nuclei and their cytogically determined activity diminished. These structurally fixed adaptational changes in the hormonal control caused a stable decrease in the reseves of sodium and water in the organism of the adapted animals. This complex of shifts is contrary to the changes developing in all forms of experimental hypertension and in hypertensive disease in humans. The idea is discussed that inhibition of mineralocorticoid and ACTH secretion and the stable decrease in the sodium and water reserves in the organism during adaptation play the principal role in the mechanism of the preventive effect of adaption to altitude hypoxia in hypertension.
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