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  • Title: [Systemic arterial hypertension: pathogentic role of the sympathetic nervous system].
    Author: Andrejak M, Simon A, Hardin JM, Fournier A, Safar M, Quichaud J.
    Journal: Nouv Presse Med; 1977 Dec 10; 6(42):3963-7. PubMed ID: 600739.
    Abstract:
    Role of the clinical and experimental data suggesting the role of the sympathetic nervous system in some essential hypertension are reviewed: increase in heart rate and diastolic blood pressure during orthostatism, increase in cardiac output resulting from increase in cardiopulmonary blood volume and/or in myocardial contractility, increase in peripheral resistances, elevated plasma catecholamines and dopamine-bêta-hydroxylase, disturbances in arterial baroreceptor sensitivity and in vascular response to adrenergic stimuli, elevated plasma renin activity. It appears that the role of a sympathetic overactivity is mainly important in labile hypertension with hyperkinetic syndrome and elevated plasma renin activity.
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