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  • Title: [Anti-arrhythmic activity of the beta2-adrenoblockader alpheprol].
    Author: Gendenshteĭn EI, Kostin IV, Simon IB.
    Journal: Biull Eksp Biol Med; 1976 Jun; 81(6):694-6. PubMed ID: 60151.
    Abstract:
    Experiments were conducted on dogs, cats and rats in which various disturbances of the cardiac rhythm were induced. Beta2-adrenoblocker alpheprol proved to produce a marked antiarrhythmic action. The preparation arrested the auricular arrhythmias caused by electric stimulation of the auricles or by aconitine application, eliminated the auricular arrhythmias resulting from occlusion of a branch of the coronary artery or oubaine intoxication, prevented lethal auricular fibrillation in rats after the calcium chloride intoxication. It is supposed that along with the beta-adrenoreceptor block the antiarrhythmic effect of alpheprol was also caused by quinidine-like action of the preparation.
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