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  • Title: [High-dosage glucocorticoid therapy in acute heart infarct and in cardiogenic shock].
    Author: Krosch H, Schäbitz J.
    Journal: Z Gesamte Inn Med; 1977 Nov 15; 32(22):631-3. PubMed ID: 602316.
    Abstract:
    40 patients with cardiogenic shock in consequence of contractility insufficiency of the heart were treated with high doses of prednisolon for short time. In 10 cases a good result of the treatment was to be seen so that the lethality quota was smaller than that of a reference group of the same age. The pharmacodynamic effect is seen in an improvement of the micro-circulation by a peripheric vasodilatation. 10 patients with acute myocardial infarction got a therapy with glucocorticoid combined with a treatment with anti-coagulants during the first both weeks. In this connection modern experimental examinations of animals are discussed which showed that glucocorticoides improve the anoxy tolerance of the heart muscle cell.
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