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  • Title: [Therapeutic induction of abortion in the 1st and 2nd trimesters with intramuscular 15-methyl-prostaglandin F2 alpha].
    Author: Göretzlehner G, Rudolf K, Frahm R.
    Journal: Zentralbl Gynakol; 1977; 99(22):1356-60. PubMed ID: 602503.
    Abstract:
    The effectiveness of intramuscular 15-methyl-prostaglandin F2alpha (15-methyl-PGF2alpha) application for therapeutic abortion was studied in 16 women during the first and second trimester (12 to 17 weeks) of pregnancy. 250 microgram 15-methyl-PGF2alpha were administered initial and at intervals of 2 hours. Of the 16 subjects, 2 aborted completely, 13 aborted incompletely and 1 failed to abort. The mean abortion time for the 15 successful abortions was 11,25 hours and the mean 15-methyl-PGF2alpha dosage 1,35 mgs. Vomiting and diarrhea were the most prevalent side effects occurring in 12 of 16 patients. No serious complications occurred. In 9 women between 7 to 13 weeks of pregnancy a single intramuscular injection of 250 microgram 15-methyl-PGF2alpha was administered 11 to 13 hours prior to vacuum aspiration. All subjects had a gradual softening and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. All subjects had a gradual softning and dilatation of the cervix (5 to 8 mm). In 7 of 9 patients occurring gastro-intestinal side effects. Acute ascension was observed in 2 women after vacuum aspiration. Intramuscular administration of 15-methyl-PGF2alpha appears to be an effective abortifacient. Gastro-intestinal side effects can be reduced by antiemetic and antidiarrheal agents or lowering the initial dose of 15-methyl-PGF2alpha. Use of 15-methyl-prostaglandin F2 alpha to induce therapeutic abortion in 25 women is described. Repeated intramuscular (im) injections resulted in complete abortion in 2 patients, and incomplete abortion in 13 others. A 16th patient failed to abort. In 9 women in the 7-13th week of pregnancy, a single im injection induced cervical softening and dilatation before vacuum aspiration. Diarrhea and vomiting occurred in 19 patients. The authors recommend the use of anti-emetics and anti-diarrheals, or a lower initial dose, to control side effects. Evidence indicates 15-methyl-prostaglandin F2 alpha is a successful abortifacient.
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