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  • Title: Method for determining antineuraminidase activity.
    Author: Wagner RB, Steinberg BA, Ruchman I.
    Journal: Appl Microbiol; 1967 Mar; 15(2):239-42. PubMed ID: 6029825.
    Abstract:
    A test was developed to screen drugs for antineuraminidase (influenza sialidase) activity in vitro. Neuraminidase prepared from Vibrio cholerae was added to a substrate containing ganglioside, prepared from calf brain. Sialic acid is a split product in the reaction. The presence of sialic acid was detected colorimetrically by use of Warren's Thiobarbituric Acid Assay after drugs had been added to inhibit the action of neuraminidase on the calf brain substrate.
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