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  • Title: [Toxicity of aliphatic halogenated hydrocarbons containing fluorine].
    Author: Pantaleoni G, Zoccolillo L.
    Journal: Ann Ist Super Sanita; 1977; 13(1-2):343-51. PubMed ID: 603132.
    Abstract:
    The fluorinated propellers have a certain cardiotoxicity. They cause disturbances to the intraventricular conduction, to the inotropisme and to the arterial pressure. Such disturbances show up in the laboratory rat due to a concentration in the air that once was thought innocuous for this specie. We have analysed doses of 15%-30%-60% of CCl2F2 in the air on the tracheotomysed and curarised animals. The vagotomy protects in part from the occurence of marked alterations ECG, but not from the alterations of the cardiac mechanigram and of the arterial pressure. The arterial pressure is the cardiocirculatory parameter which remains inhibited longer when the animal is again breathing air without Freon. After breathing air without Freon for ten minutes, rats submitted to a successive dose of gas are rapidly intoxicated. Low doses of CCl2F2 in the air (5%) make rabbits ipersensitive to the "arythmies-producing" effects of the adrenaline.
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