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  • Title: The binding of inhibitors to alpha-chymotrypsin at alkaline pH.
    Author: Johnson CH, Knowles JR.
    Journal: Biochem J; 1967 May; 103(2):428-30. PubMed ID: 6032980.
    Abstract:
    1. The binding of the competitive inhibitor N-acetyl-d-tryptophan amide to alpha-chymotrypsin has now been studied at pH values up to 10.6, by the technique of equilibrium dialysis. 2. This binding depends on the ionization of a group on the free enzyme with apparent pK(a) 9.3 at 5 degrees . 3. This group is tentatively identified as that responsible for an enzyme conformation change at high pH values, on which the catalytic activity of the enzyme also depends.
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