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  • Title: Electrical phenomena associated with the activity of the membrane-bound acetylcholinesterase.
    Author: Podleski T, Changeux JP.
    Journal: Science; 1967 Sep 29; 157(3796):1579-81. PubMed ID: 6038174.
    Abstract:
    Treatment of isolated electroplax with physiological solutions supplemented with either 1 molar sodium chloride, 2 molar urea, or 2 molar sucrose renders the cell insensitive to carbamylcholine, phenyltrimethylammonium, or decamethonium even at high concentrations. The treated cells have a residual resting potential of -20 +/- 10 millivolts (negative inside) and are depolarized by acetylcholine at concentrations larger than 10(-3) mole per liter. This response is not affected by d-tubocurarine but is blocked by physostigmine, diisopropylphosphorofluoridate, or strong buffers and thus depends on the catalytic activity of the membrane-bound acetylcholinesterase.
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