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  • Title: HLA and pancreatic islet cell antibodies in diabetes.
    Author: Morris PJ, Irvine WJ, Gray RS, Duncan LJ, Vaughan H, McCallum FJ, Campbell CJ, Farquhar JW.
    Journal: Lancet; 1976 Sep 25; 2(7987):652-3. PubMed ID: 60516.
    Abstract:
    The frequency of HLA-B8 was significantly increased in pancreatic islet cell antibody (P.I.C.A)-positive patients (61%) compared with P.I.C.A.-negative patients (35%) and a control population (28%). This increased frequency of HLA-B8 was even more striking in diabetics in whom P.I.C.A. persisted for more than 5 years (71%). Thus the association of HLA-B8 with diabetes may be related to the presence of P.I.C.A. in these patients.
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