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  • Title: HLA gene and haplotype frequencies in spina bifida. Population and family studies.
    Author: De Bruyere M, Kulakowski S, Malchaire J, Delire M, Sokal G.
    Journal: Tissue Antigens; 1977 Nov; 10(5):399-402. PubMed ID: 605436.
    Abstract:
    The search for HLA association in spina bifida is particularly interesting since this condition can be associated with the effects of the T locus in mice. Gene and haplotype frequencies in 32 unrelated patients suffering from spina bifida were studied. Gene frequency of HLA-B5 and haplotype frequency of A2, B5 were increased without reaching signification levels. Fourteen families were examined clinically and radiologically. A high frequency of spina bifida occulta and other vertebral abnormalities was found without evidence of linkage with HLA haplotypes.
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