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  • Title: In vitro studies on antibody production by lymph node cells using cell electrophoresis.
    Author: Sundaram K, Phondke GP, Sundaresan P.
    Journal: Immunology; 1967 Oct; 13(4):433-9. PubMed ID: 6055755.
    Abstract:
    Investigations were undertaken on rat lymph node cell suspensions using cell electrophoretic techniques: (a) to examine the specificity of antigen—antibody binding, (b) to determine any relationship between the electrophoretic mobility pattern and antibody production, and (c) to estimate the potentiality of a single cell to produce antibody to more than one antigen at the same time. The results, in brief, indicate that a drastic reduction in the mean mobility is caused when the immunized cells are treated with the same antigen used for immunization. These interactions have antigenic specificity. In addition, it has been shown that not all cells in a lymph node produce antibodies and the percentage of cells that produce antibodies changes from day to day. The maximum response occurs between the 4th and 5th day of the second antigenic administration. Studies with simultaneous administration of two bacterial antigens support the concept that by and large a lymph node cell produces specific antibodies to only one antigen at a time.
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