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  • Title: Serum enzyme changes associated with carbon disulfide hepatotoxicity in experimental animals.
    Author: El-Dessoukey EA, Awadallah R, Mikhail TH.
    Journal: Z Ernahrungswiss; 1977 Dec; 16(4):262-7. PubMed ID: 605628.
    Abstract:
    Investigations were performed to evaluate the activities of serum glutamic oxalacetic and glutamic pyruvic transaminases, alkaline phosphatase and lactate-dehydrogenase enzymes in rats intoxicated by different doses of carbon disulfide. Serum GOT and GPT activities were elevated which may be due to CS2 effect on cell membrane permeability. Serum-alkaline-phosphatase activity showed also increment, which was again attributed to the liver affection. A significant rise in serum-lactate-dehydrogenase activity which was referred to be as a result of muscle-lactate dehydrogenase release into the blood circulation.
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