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  • Title: Synthesis of tenuazonic acid analogues.
    Author: Soliman FS.
    Journal: Pharmazie; 1977 Oct; 32(10):572-5. PubMed ID: 607213.
    Abstract:
    The synthesis of two 1.5-diaryltetramic acids, aryl analogues of tenuazonic acid, is described. The reactivity of position 4 of these tetramic acids towards primary and secondary amines, and o-methylation led to the synthesis of 4-substituted-delta3-pyrroline-2-one. Further, reactivity of position 3 has been indicated by the formation of 3-arylidenepyrrolidine-2.4-diones and by diazo-coupling. The structures assigned to the new compounds are substantiated by IR and NMR data.
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