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  • Title: Inhibition by estramustine phosphate on estradiol and androgen binding in benign and malignant prostate in humans.
    Author: Nilsson I, Liskowski L, Nilsson T.
    Journal: Urology; 1976 Aug; 8(2):118-21. PubMed ID: 60819.
    Abstract:
    Specific cytoplasmic androgen and estrogen binding has been measured in human benign prostatic hypertrophy and carcinomatous tissue. In vitro support for the binding of estramustine phosphate (Estracyt) to both estradiol- and dihydrotestosterone-binding sites is presented, which in part could explain the clinical effect of estramustine phosphate when pure estrogenic compunds are not effective.
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