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  • Title: Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists.
    Author: Chand N, Diamantis W, Pillar J, Sofia RD.
    Journal: Br J Pharmacol; 1984 Dec; 83(4):899-902. PubMed ID: 6083814.
    Abstract:
    Bepridil, TMB-8 (8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride), diltiazem, verapamil and nifedipine exerted concentration-dependent inhibition of antigen and calcium ionophore A23187-induced histamine release from rat peritoneal mast cells. The inhibitory effects of verapamil and bepridil against calcium ionophore A23187-induced histamine secretion were antagonized by increased Ca2+ concentrations in the extracellular medium. These observations suggest that both agents act by interfering with the influx of Ca2+ into the mast cells. The inhibitory activities of five different Ca2+ channel blockers on allergic and non-allergic histamine secretion from rat peritoneal mast cells varied considerably depending upon the nature of the secretagogue as well as concentration and type of Ca2+-antagonist examined.
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