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  • Title: Splenic granulopoietic morphology in laboratory rats after experimental induction of marrow hypoplasia.
    Author: Berger J.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1984; 111(5):604-9. PubMed ID: 6083934.
    Abstract:
    Within the granulopoietic recovery phase the proportion of neutrophils and their precursors in the spleen was elevated from 1.7 +/- 0.3% (controls) to 14.7 +/- 2.2% (on day 14 after cyclophosphamide). Splenic granulopoiesis persisted for a time after the appearance of marrow recovery. These data suggest that the rat adult spleen can become a markedly granulopoietic organ during the regeneration of granulopoiesis which follows experimentally induced myelosuppression.
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