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  • Title: Effect of diamide (azodicarboxylic acid-bis-dimethylamide) on arachidonic acid release from human blood platelet phospholipids.
    Author: Lösche W, Michel E, Thielmann K, Till U.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1984; 111(6):769-73. PubMed ID: 6083952.
    Abstract:
    It was found that the thiol-oxidizing agent diamide inhibits the formation of arachidonic acid metabolites in thrombin-stimulated platelets. An inhibition of arachidonic acid release from membrane phospholipids in diamide-treated platelets is concluded since diamide does not diminish the formation of stable metabolites from exogenous arachidonic acid. The role of the cellular thiol-disulfide status for the activities of phospholipases involved in arachidonic acid release is discussed.
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