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  • Title: Proteinases and inhibitors in plasma and peritoneal exudate in acute pancreatitis.
    Author: Wendt P, Fritsch A, Schulz F, Wunderlich G, Blümel G.
    Journal: Hepatogastroenterology; 1984 Dec; 31(6):277-81. PubMed ID: 6083967.
    Abstract:
    Examination of the peritoneal exudates of 12 patients with acute pancreatitis revealed high activities of pancreatic lipase and amylase. The immunologic levels of the plasma-derived inhibitors alpha 1-antitrypsin, antithrombin III and alpha 2-macroglobulin in the peritoneal exudates were not markedly different from those of the plasma. However, the inhibitory capacity of alpha 2-macroglobulin, the main inhibitor of human pancreatic trypsin in the exudate, was almost completely depleted when measured by an enzymatic method. Furthermore, spontaneous fibrinolysis occurred in 6 out of 13 exudates applied to plasminogen-free fibrin plates, indicating the presence of free proteinase. This fibrinolytic activity might be inhibited by exogenous alpha 2-macroglobulin or aprotinin (Trasylol, Bayer AG).
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