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  • Title: Early kinetics of Ca2+ fluxes and histamine release in rat mast cells stimulated with compound 48/80.
    Author: McClain DE, Donlon MA, Hill TA, Catravas GN.
    Journal: Agents Actions; 1984 Oct; 15(3-4):279-84. PubMed ID: 6084412.
    Abstract:
    The kinetics of Ca2+ uptake and efflux have been measured in rat peritoneal mast cells stimulated with compound 48/80 using rapid mixing and a silicone oil centrifugation technique. Responses at one-second time intervals were resolved beginning as early as three seconds after initial stimulation. The results clearly demonstrate that Ca2+ uptake occurs after the initiation of histamine release. Ca2+ efflux occurs simultaneously with histamine release. The implications of these findings are discussed and the technique is described.
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